Reaction: NEIL3 cleaves thymine glycol from telomeric DNA
- in pathway: Cleavage of the damaged pyrimidine
NEIL3 cleaves oxidatively damaged thymine in the form of thymine glycol (Tg) from telomeric DNA, producing an abasic (AP) site (Zhou et al. 2013). NEIL3 prefers Tg damages in telomeric DNA over random sequences.
Reaction - small molecule participants:
Tg [nucleoplasm]
Reactome.org reaction link: R-HSA-9629497
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Reaction input - small molecules:
Reaction output - small molecules:
thymine glycol
Reactome.org link: R-HSA-9629497