Reaction: NEIL3 cleaves thymine glycol
- in pathway: Cleavage of the damaged pyrimidine
NEIL3 cleaves oxidatively damaged thymine in the form of thymine glycol (Tg) with a preference for single strand DNA (ssDNA) over double strand DNA (dsDNA), producing an abasic (AP) site (Liu et al. 2010, Zhou et al. 2013).
Reaction - small molecule participants:
Tg [nucleoplasm]
Reactome.org reaction link: R-HSA-9629499
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Reaction input - small molecules:
Reaction output - small molecules:
thymine glycol
Reactome.org link: R-HSA-9629499