Reaction: HSPA8:substrate binds late endosomal phospholipids
- in pathway: Late endosomal microautophagy
Microautophagy (MI) can target KFERQ motif containing protein substrates to endosomal degradation. Upon binding with HSPA8, substrates are transported from the cytosol to late endosomes. Here, HSPA8 binds with the phospholipids on the late endosomal membrane. This interaction facilitates the vesicle-mediated transport of HSPA8:substrate complex into the late endosomes for degradation (Sahu R et al. 2011). Experiments confirming this interaction were performed in mouse cells.
Reaction - small molecule participants:
PL [late endosome membrane]
Reactome.org reaction link: R-HSA-9631068
======
Reaction input - small molecules:
phospholipid
Reaction output - small molecules:
Reactome.org link: R-HSA-9631068