Reaction: LINC01139 promotes phosphorylation of HIF1A by LRRK2
- in pathway: PTK6 promotes HIF1A stabilization
LRRK2 serine/threonine kinase, activated via long non-coding RNA LINC01139 (LINK-A) mediated recruitment to phosphorylated GPNMB (bound to HBEGF-activated EGFR), phosphorylates hypoxia inducible factor 1 alpha (HIF1A) at serine residue S797. LRRK2-mediated phosphorylation of HIF1A at S797 promotes association of HIF1A with EP300 (p300) transcriptional co-activator and inhibits association of HIF1A with a transactivation inhibitor HIF1AN (FIH) (Lin et al. 2016).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9634702
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9634702