Reaction: PtpA dephosphorylates GSK3A
- in pathway: Suppression of apoptosis
Mtb infection inhibits the cleavage of inactive caspase-3 into its active forms by dephosphorylation of human glycogen synthase kinase-3 alpha (GSK3α). Tyr-279 is essential for the full activity of GSK3α. Mtb protein tyrosine phosphatase (PtpA) dephosphorylates Tyr-279 and thereby inactivates GSK3α (Poirier et al. 2014).
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9635461
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-9635461