Reaction: PTPN7 dephosphorylates p-T,Y-MAPKs

- in pathway: Negative regulation of MAPK pathway
Protein tyrosine phosphatase PTPN7 (also known as HePTP) dephosphorylates tyrosine residues of MAPK1 (ERK2) (Saxena et al. 1999, Pettiford and Herbst 2000) and MAPK3 (ERK1) (Saxena et al. 1999), leading to reduction in their catalytic activity.
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9635739

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Reaction input - small molecules:
water
ChEBI:15377
Reaction output - small molecules:
hydrogenphosphate
ChEBI:43474
Reactome.org link: R-HSA-9635739