Reaction: ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP
- in pathway: Prevention of phagosomal-lysosomal fusion
Ras-related protein with guanosine 5'-triphosphates bound to GTP (RAB5A:GTP,RAB7A:GTP) get deactivated through dephosphorylation of GTP via the GTPase-activating protein (GAP)-like activity of the Mtb nucleoside diphosphate kinase (ndkA) (Chopra et al. 2004, Sun et al. 2010).
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9636684
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-9636684