Reaction: CpnT hydrolyses NAD+
- in pathway: Phagocyte cell death caused by cytosolic Mtb
The C-terminal domain of CpnT, tuberculosis necrotizing toxin (TNT) has NAD+ hydrolase activity. Its secretion depletes NAD+ in the cytosol of the phagocyte which leads to necrosis (Sun et al. 2015).
Reaction - small molecule participants:
NAM [cytosol]
H+ [cytosol]
ADP-D-ribose [cytosol]
H2O [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-9637699
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Reaction input - small molecules:
water
NAD(1-)
Reaction output - small molecules:
nicotinamide
hydron
ADP-D-ribose(2-)
Reactome.org link: R-HSA-9637699