Reaction: B3GAT3 dimer transfers GlcA to tetrasaccharide linker
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3) (Ouzzine et al. 2000) transfer a glucuronate (GlcA) residue via a beta1,3-linkage to a terminal galactose. The B3GATs are homodimeric and require manganese as a cofactor (Kakuda et al. 2004, Ouzzine et al. 2000). The tetrasaccharide linker is now complete, ready to accept further hexosamine additions. The type of hexosamine added is critical in determining which glycosaminoglycan (GAG) is formed.
Reaction - small molecule participants:
UDP [Golgi lumen]
UDP-GlcA [Golgi lumen]
Reactome.org reaction link: R-HSA-9638064
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Reaction input - small molecules:
UDP-alpha-D-glucuronate(3-)
Reaction output - small molecules:
UDP(3-)
Reactome.org link: R-HSA-9638064