Reaction: B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA
- in pathway: O-linked glycosylation
Glycosyltransferase-like protein LARGE is a bifunctional glycosyltransferases with both xylosyltransferase and beta-1,3-glucuronyltransferase activities which can form polymeric Xyl-GlcA repeats. LARGE is involved in the physiological function of alpha-dystroglycan (DAG1) which plays a key role in skeletal muscle function and regeneration (Inamori et al. 2013, Wells 2013, Inamori et al. 2014).
Reaction - small molecule participants:
GlcA-Xyl-GlcA [Golgi lumen]
UDP [Golgi lumen]
UDP-GlcA [Golgi lumen]
Xyl-GlcA [Golgi lumen]
Reactome.org reaction link: R-HSA-9638097
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Reaction input - small molecules:
UDP-alpha-D-glucuronate(3-)
alpha-D-Xyl-(1->3)-beta-D-GlcA
Reaction output - small molecules:
beta-D-GlcA-(1->3)-alpha-D-Xyl-(1->3)-beta-D-GlcA
UDP(3-)
Reactome.org link: R-HSA-9638097