Reaction: Ca2+ binds KCNIP3
- in pathway: Regulation of NPAS4 gene transcription
Upon neuronal activity-induced influx of calcium ions, Ca2+ binds to KCNIP3 homotetramers. Calcium-bound KCNIP3 cannot associate with target DNA sequences (Carrion et al. 1999). Based on studies with mouse Kcnip3, which has amino acid sequence 91% identical to human KCNIP3, Ca2+ binds to two high-affinity sites in Kcnip3 under physiological conditions, when magnesium is present. In the absence of magnesium, Ca2+ can bind to three sites in KCNIP3 (Osawa et al. 2005).
Reaction - small molecule participants:
Mg2+ [nucleoplasm]
Ca2+ [nucleoplasm]
Reactome.org reaction link: R-HSA-9640063
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
magnesium(2+)
Reactome.org link: R-HSA-9640063