Meta-Biol

• Pathways

The GTPase activity of RRAGA,B hydrolyzes GTP to GDP (Bar-Peled et al. 2013). RRAGA and RRAGB lack detectable GTPase activity in the absence of a GTPase activating protein (Schurmann et al. 1995). The NPRL2 subunit of the GATOR1 complex acts as a GTPase activator of RRAGA,B and thereby controls the guanyl nucleotide bound to RRAGA,B (Bar-Peled et al. 2013, Shen et al. 2019). GATOR2 antagonizes GATOR1 (Bar-Peled et al. 2013). During amino acid deficiency, Sestrins (SESN1 and SESN2) (Chantranupong et al. 2014, Parmigiani et al. 2014, Peng et al. 2014, Kim et al. 2015, Wolfson et al. 2016, Saxton et al. 2016) and CASTOR1 (Chantranupong et al. 2016, Saxton et al. 2016, Gai et al. 2016, Xia et al. 2016) bound to GATOR2 prevent GATOR2 from antagonizing GATOR1 (Bar-Peled et al. 2013). BMT2 (SAMTOR) bound to GATOR1 enhances inhibition of mTORC1 activation by GATOR1 (Gu et al. 2017).