Reaction: BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1
- in pathway: Amino acids regulate mTORC1
BMT2 (SAMTOR) binds GATOR1 and acts upstream of GATOR1 and KICSTOR to inhibit mTORC1 activation (Gu et al. 2017). Upon binding S-adenosymethionine, a metabolic derivative of the amino acid methionine, SAMTOR dissociates from GATOR1 and mTORC1 activity is increased through an uncharacterized mechanism (Gu et al. 2017). GATOR1 is recruited to the lysosomal membrane by the KICSTOR complex (Wolfson et al. 2017).
Reaction - small molecule participants:
AdoMet [cytosol]
Reactome.org reaction link: R-HSA-9640254
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
Reactome.org link: R-HSA-9640254