Reaction: pro-RAS proteins are farnesylated
- in pathway: RAS processing
RAS proteins are isoprenylated at a CaaX motif in the hypervariable region, where a is an aliphatic amino acid and X is any amino acid (Casey et al, 1989; Dharmaiah et al, 2016; reviewed in Ahean et al, 2018). Geranylgeranylation is favoured when X is leucine, while all other amino acids at this position favour farnesylation by farnesyltransferase (Casey et al, 1989; Reid et al, 2004).
Reaction - small molecule participants:
PPi [cytosol]
FPP [cytosol]
Reactome.org reaction link: R-HSA-9647978
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Reaction input - small molecules:
farnesyl diphosphate
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-9647978