Reaction: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
- in pathway: RAS processing
After carboxymethylation, HRAS, NRAS and KRAS4A are palmitoylated on cysteine residues upstream of the CaaX motif (residue C179 in KRAS4A, C181 in NRAS and C181 and C184 in HRAS). KRAS4B lacks upstream cysteine residues and does not undergo palmitoylation (Hancock et al, 1989; Swarthout et al, 2005; reviewed in Gysin et al, 2011; Ahearn et al, 2018). Palmitoylation is catalyzed by the DHHC9:GOLGA7 complex at the Golgi membrane (Swarthout et al, 2008).
Reaction - small molecule participants:
CoA-SH [cytosol]
PALM-CoA [cytosol]
Reactome.org reaction link: R-HSA-9647982
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Reaction input - small molecules:
palmitoyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-9647982