Reaction: NEK6 and NEK7 phosphorylate EML4
- in pathway: EML4 and NUDC in mitotic spindle formation
At mitotic entry, EML4 undergoes phosphorylation on serine and/or threonine residues (Pollmann et al. 2006). NEK6 and NEK7 serine/threonine kinases phosphorylate EML4 at evolutionarily conserved serine residues S144 and S146. Phosphorylation of EML4 at S144 and S146 reduces the affinity of EML4 for microtubules, leading to an increase in microtubule instability that is necessary for the assembly of a dynamic mitotic spindle and successful segregation of duplicated chromosomes (Adib et al. 2019).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9648089
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9648089