Reaction: Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer
- in pathway: Response of EIF2AK1 (HRI) to heme deficiency
One molecule of hemin (ferriheme b chloride) tightly binds the N-terminal domain of EIF2AK1 (HRI) and one molecule of hemin loosely binds the kinase insert (KI) domain of EIF2AK1 (Bhavnani et al. 2018, and inferred from rabbit and mouse homologs). When cytosolic heme concentrations are low, heme dissociates from the KI domain, resulting in activation of the kinase activity of EIF2AK1 (inferred from rabbit and mouse homologs).
Reaction - small molecule participants:
FeHM [cytosol]
Reactome.org reaction link: R-HSA-9648880
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Reaction input - small molecules:
Reaction output - small molecules:
ferriheme b
Reactome.org link: R-HSA-9648880