Reaction: p-T-EIF2AK1:ferriheme dimer autophosphorylates
- in pathway: Response of EIF2AK1 (HRI) to heme deficiency
During heme deficiency, EIF2AK1 (HRI) autophosphorylates, notably on threonine residues in the activation loop (inferred from the mouse homolog). EIF2AK1 also has many phosphorylated residues prior to activation in response to heme deficiency (inferred from the mouse homolog). Autophosphorylation of threonine-488 (threonine-485 in the mouse homolog) is essential for kinase activity of EIF2AK1 acting on EIF2S1 (eIF2-alpha) in response to heme deficiency and oxidative stress by arsenite (inferred from the mouse homolog).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9648883
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9648883