Reaction: HTR3A pentamer binds 5HT
The 5-hydroxytryptamine receptor (HTR3) family are members of the superfamily of ligand-gated ion channels (LGICs). Five receptors (HTR3A-E) can form a homopentamer (HTR3A) or heteropentamers (HTR3A with B, C, D or E) (Barrera et al. 2005, Niesler et al. 2007; reviews - Barnes et al. 2009, Wu et al. 2015). Binding of the neurotransmitter 5-hydroxytryptamine (5HT, serotonin) to the HTR3 pentamer opens the channel making it permeable to sodium, potassium, and calcium ions, which in turn leads to an excitatory response in neurons (Miyake et al. 1995, Davies et al. 1999).
Reaction - small molecule participants:
5HT [extracellular region]
Reactome.org reaction link: R-HSA-9649108
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Reaction input - small molecules:
serotonin(1+)
Reaction output - small molecules:
Reactome.org link: R-HSA-9649108