Reaction: mature p21 RAS binds GDP
- in pathway: RAS processing
RAS proteins bind GDP with picomolar affinity as part of the RAS:GTP cycle (reviewed in Hennig et al, 2015; Pei et al, 2019; Prior et al, 2012). RAS proteins in the GDP-bound form are inactive. Interaction with guanine nucleotide exchange factors (GEFs) enhances the slow rate of intrinsic GDP dissociation, allowing GTP to bind and activate the protein (reviewed in Henning et al, 2015).
Reaction - small molecule participants:
GDP [cytosol]
Reactome.org reaction link: R-HSA-9649733
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Reaction input - small molecules:
GDP(3-)
Reaction output - small molecules:
Reactome.org link: R-HSA-9649733