Reaction: THTPA:Mg2+ hydrolyzes ThTP to TDP
- in pathway: Vitamin B1 (thiamin) metabolism
Thiamin triphosphate (ThTP) can transfer phosphate to a few proteins. Animal tissues contain a membrane-associated as well as a soluble thiamine triphosphatase that can dephosphorylate ThTP. Only the soluble enzyme was characterized in calf (Lakaye et al, 2002).
Reaction - small molecule participants:
Pi [cytosol]
ThDP [cytosol]
H2O [cytosol]
ThTP [cytosol]
Reactome.org reaction link: R-HSA-965067
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Reaction input - small molecules:
water
thiamine(1+) triphosphate
Reaction output - small molecules:
hydrogenphosphate
thiamine(1+) diphosphate(3-)
Reactome.org link: R-HSA-965067