Reaction: Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs
- in pathway: Signaling by MAPK mutants
Constitutively active forms of MAPK1 have been identified at low frequency in a number of cancers (Ojesina et al, 2014; TCGA, 2015). These mutants are not susceptible to DUSP-mediated dephosphorylation and so promote sustained signaling (Brenan et al, 2016).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9652816
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9652816