Reaction: GABA translocates from cytosol to mitochondrial matrix
- in pathway: Degradation of GABA
GABA (gamma-aminobutyrate) is transported across the inner mitochondrial membrane into the mitochondrial matrix. Studies of isolated mitochondria from rat and mouse brains together showed that GABA uptake into isolated mitochondria is energy- and Na+-dependent (Berkich et al. 2007; Kuriyama et al. 1969; Passarella et al. 1984), and Michaeli et al. (2011) have characterized an Arabidopsis protein that mediates mitochondrial GABA uptake, but no mammalian mitochondrial GABA transporter has been identified.
Reaction - small molecule participants:
GABA [mitochondrial matrix]
GABA [cytosol]
Reactome.org reaction link: R-HSA-9653180
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Reaction input - small molecules:
gamma-aminobutyric acid zwitterion
Reaction output - small molecules:
gamma-aminobutyric acid zwitterion
Reactome.org link: R-HSA-9653180