Reaction: USP17L2 deubiquitinates RCE1
- in pathway: RAS processing
USP17L2, also known as USP17, deubiquitinates RCE1 (RAS-converting enzyme 1), inactivating it. Loss of RCE1 activity after USP17L2-mediated deubiquitination interferes with RAS localization and function and prevents downstream signaling through the RAF MAP kinase cascade (Burrows et al, 2009).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9653514
======
Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9653514