Reaction: SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
- in pathway: Heme degradation
Bilirubin (BIL), the end product of heme catabolism, is taken up from the blood circulation into the liver. The organic anion transporting polypeptide SLCO1B1 (OATP, OATP2, OATPC, SLC21A6), localised on the basolateral (sinusoidal side) hepatocyte membrane, can mediate the uptake of BIL and various other lipophilic anions into the human liver (Konig et al. 2000, Cui et al. 2001).
Reaction - small molecule participants:
BIL [cytosol]
BIL [extracellular region]
Reactome.org reaction link: R-HSA-9661397
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Reaction input - small molecules:
bilirubin(2-)
Reaction output - small molecules:
bilirubin(2-)
Reactome.org link: R-HSA-9661397