Reaction: SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
- in pathway: Heme degradation
Bilirubin (BIL), the end product of heme catabolism, is taken up from the blood circulation into the liver. The solute carrier organic anion transporter family member 2B1 (SLCO2B1, aka OATPRP2, OATPB, SLC21A9), localised on the basolateral (sinusoidal side) hepatocyte membrane, can mediate the uptake of BIL and various other lipophilic anions into the human liver (Kullak-Ublick et al. 2001). The predominant isoform in the liver is SLCO2B1 isoform 3 (Knauer et al. 2013).
Reaction - small molecule participants:
BIL [cytosol]
BIL [extracellular region]
Reactome.org reaction link: R-HSA-9661723
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Reaction input - small molecules:
bilirubin(2-)
Reaction output - small molecules:
bilirubin(2-)
Reactome.org link: R-HSA-9661723