Reaction: An unknown BILR reduces BIL to D-UBGN
- in pathway: Heme degradation
Microbes present in the large intestine reduce bilirubin (BIL) to D-urobilinogen (D-UBGN) (Troxler et al. 1968, Watson et al. 1958, Vitek et al. 2006). The identity of the bilirubin reductase (BILR) is unknown (Koníčková et al. 2012). Some D-UBGN can be reabsorbed into the portal circulation and delivered to the liver where it is recycled back into the biliary flow.
Reaction - small molecule participants:
D-UBGN [extracellular region]
an oxidized electron acceptor [extracellular region]
BIL [extracellular region]
a reduced electron acceptor [extracellular region]
Reactome.org reaction link: R-HSA-9661745
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Reaction input - small molecules:
bilirubin(2-)
electron acceptor
Reaction output - small molecules:
D-Urobilinogen
electron acceptor
Reactome.org link: R-HSA-9661745