Reaction: SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
- in pathway: Heme degradation
Bilirubin (BIL), the end product of heme catabolism, is taken up from the blood circulation into the liver. The organic anion transporting polypeptide (SLCO1B3, aka OATP-8, LST2, SLC21A8), localised on the basolateral (sinusoidal side) hepatocyte membrane, can mediate the uptake of BIL and various other lipophilic anions into the human liver (van de Steeg et al. 2012).
Reaction - small molecule participants:
BIL [cytosol]
BIL [extracellular region]
Reactome.org reaction link: R-HSA-9661799
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Reaction input - small molecules:
bilirubin(2-)
Reaction output - small molecules:
bilirubin(2-)
Reactome.org link: R-HSA-9661799