Meta-Biol

• Pathways

ATP2B2 (wa isoform) is located in the plasma membrane of stereocilia bundles of inner hair cells and outer hair cells and transports calcium ions from the cytosol to the extracellular region with concomitant hydrolysis of ATP (Ficarella et al. 2007, Giacomello et al. 2011, and observed in rat and mouse). ATP2B2 appears to facilitate an efflux of calcium ions that enter the stereocilia during depolarization caused by the opening of the mechanoelectrical transduction channel, hence ATP2B2 plays a role in repolarization of the cell (Ficarella et al. 2007, Giacomello et al. 2011, and observed in rat and mouse).