Reaction: PLK2, MAPK14 phosphorylate ADAM17
- in pathway: CD163 mediating an anti-inflammatory response
The phosphorylation of disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) by PLK2 and MAPKs has been determined by direct and indirect experiments (Müllberg et al. 1993, Schwarz et al. 2014, Fan and Derynck 1999; Gechtman et al. 1999; Díaz-Rodríguez et al. 2002; Fan, Turck, and Derynck 2003 & Xu and Derynck 2010). Specifically, the phosphorylation at residues Thr735 (Díaz-Rodríguez et al. 2002 & Xu and Derynck 2010) and Ser819 is required for ectodomains shedding.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9662823
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9662823