Reaction: CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol
- in pathway: Acetylcholine inhibits contraction of outer hair cells
In response to binding acetylcholine (AcCho), the CHRNA9:CHRNA10 receptor transports calcium ions from the extracellular region to the cytosol (inferred from rat homologs). CHRNA9:CHRNA10 receptors are clustered at cholinergic synapses in the basal region of outer hair cells (OHCs) (inferred from rat homologs). The influx of calcium causes opening of SK2 channels (KCNN2) and BK channels (KCNMA1:KCNMB1), efflux of potassium ions, hyperpolarization, and inhibition of contraction of the OHCs.
Reaction - small molecule participants:
Ca2+ [cytosol]
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-9663785
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
calcium(2+)
Reactome.org link: R-HSA-9663785