Reaction: LTC4 binds CyslTR1,2
- in pathway: LTC4-CYSLTR mediated IL4 production
The cysteinyl-leukotrienes (cys-LTs) are potent smooth muscle contractile agents mediating bronchoconstriction. Examples are LTC4, LTD4 and LTE4. There are two human cys-LT receptors, 1 (Lynch KR et al, 1999) and 2 (Heise CE et al, 2000). They mediate their effects via coupling to the G protein alpha q/11 subunit (Sarau HM et al, 1999). However, signalling downstream LTC4-cysLTR binding has been associated with the production of IL4, independent of the GPCR associated heterotrimeric protein Gq (Bandeira Melo et al. 2002).
Reaction - small molecule participants:
LTC4 [extracellular region]
Reactome.org reaction link: R-HSA-9664306
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Reaction input - small molecules:
leukotriene C4
Reaction output - small molecules:
Reactome.org link: R-HSA-9664306