Meta-Biol

• Pathways

It is assumed that the following EGFR-binding ERBB2 mutants that were shown to activate PLCG1 (PLCgamma-1) signaling, evidenced by activating phosphorylation of PLCG1, recruit and phosphorylate PLCG1:

ERBB2 L755S (Bose et al. 2013);
ERBB2 I767M (Bose et al. 2013);
ERBB2 D769H (Bose et al. 2013);
ERBB2 D769Y (Bose et al. 2013);
ERBB2 V777L (Bose et al. 2013);
ERBB2 G778_P780dup (Bose et al. 2013);
ERBB2 V842I (Bose et al. 2013);
ERBB2 H878Y (Hu, Hu et al. 2015, Hu, Wan et al. 2015);
ERBB2 R896C (Bose et al. 2013);

It is assumed that, like the wild type ERBB2:EGFR heterodimer, phosphorylated heterodimers of these ERBB2 KD mutants and EGFR recruit PLCG1.

ERBB2 L755_T759del does not activate PLCG1 signaling (Bose et al. 2013).

Activation of PLCG1 downstream of the following PLCG1 mutants has not been studied and they are annotated as candidates:

ERBB2 L755M
ERBB2 L755W
ERBB2 D769N
ERBB2 V777M
ERBB2 V777E
ERBB2 V842E
ERBB2 H878R
ERBB2 R896H