Reaction: KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region
- in pathway: Acetylcholine inhibits contraction of outer hair cells
Big potassium current channels (BK channels, tetramers of KCNMA1:KCNMB1) in outer hair cells (OHCs) open in response to an influx of calcium ions, thereby causing an efflux of potassium ions which hyperpolarizes the OHC and prevents the OHC from contracting (inferred from mouse homologs and rat homologs).
Reaction - small molecule participants:
K+ [extracellular region]
K+ [cytosol]
Reactome.org reaction link: R-HSA-9667809
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Reaction input - small molecules:
potassium(1+)
Reaction output - small molecules:
potassium(1+)
Reactome.org link: R-HSA-9667809