Reaction: ANKLE2 is deacetylated by SIRT2
- in pathway: Initiation of Nuclear Envelope (NE) Reformation
ANKLE2 (LEM4) is required for normal nuclear envelope (NE) formation at the end of mitosis (Ascencio et al. 2012, Kaufmann et al. 2016). Deacetylation of ANKLE2 on residue K302 by SIRT2 promotes this process (Kaufman et al. 2016).
Reaction - small molecule participants:
NAM [cytosol]
2'-O-acetyl-ADP-ribose [cytosol]
H2O [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-9667952
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Reaction input - small molecules:
water
NAD(1-)
Reaction output - small molecules:
nicotinamide
2''-O-acetyl-ADP-D-ribose
Reactome.org link: R-HSA-9667952