Reaction: VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
- in pathway: Sealing of the nuclear envelope (NE) by ESCRT-III
The AAA+ ATPase action of VPS4 causes reorganization/disassembly of ESCRT-III filaments, which leads to membrane fusion and sealing of nuclear envelope holes (Vietri et al. 2015).
Reaction - small molecule participants:
Pi [cytosol]
H+ [cytosol]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9668415
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Reaction input - small molecules:
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
hydron
ADP(3-)
Reactome.org link: R-HSA-9668415