Reaction: Phosphorylation of juxtamembrane domain KIT mutants
- in pathway: Signaling by juxtamembrane domain KIT mutants
Juxtamembrane mutations in KIT lead to constitutive, ligand-independent autophosphorylation of receptor, activating downstream signaling (Hirota et al, 1998; Kitayama et al, 1995; Tsujimura et al, 1994; Furitsu et al, 1993; reviewed in Roskoski, 2018).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9669911
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9669911