Reaction: Autophosphorylation of PDGFRA extracellular domain dimers
- in pathway: Signaling by PDGFRA extracellular domain mutants
Constitutively active extracellular domain mutants of PDGFRA are trans-autophosphorylated at internal compartments in the absence of stimulation by ligand (Clarke and Dirks, 2003; Ozawa et al, 2010; Paugh et al 2013; Ip et al, 2018).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9672173
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9672173