Reaction: Autophosphorylation of PDGFR mutant dimers
Activating mutations in the kinase, juxtamembrane and transmembrane domains of PDGFRA lead to constitutive, ligand-independent dimerization and trans-autophosphorylation, and stimulate downstream signaling pathways (Heinrich et al, 2003; Hirota et al, 2003; Corless et al, 2005; Velghe et al, 2014; reviewed in Roskoski et al, 2018; Klug et al, 2018).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9672175
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9672175