Reaction: Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins
- in pathway: Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Where examined, cytosolic fusion proteins of PDGFRA and B have been shown to undergo constitutive trans-autophosphorylation in the absence of ligand (Cools et al, 2003; Stover et al, 2006; Salemi et al, 2009; reviewed in Reilly et al, 2003; Wang et al, 2016; Appiah-Kubi et al, 2017). Although downstream signaling has not been investigated in detail, the FIP1L1-PDGFRA fusion has been shown to signal through STAT5 and its expression in Ba/F3 murine cell line promotes oncogenic transformation (Cools et al, 2003).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9673756
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9673756