Reaction: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1
- in pathway: Signaling by CSF3 (G-CSF)
JAK1 is phosphorylated by an unknown kinase in response to CSF3 binding CSF3R (Nicholson et al. 1994, Tian et al. 1994, Marino and Roguin 2008). Phosphorylated JAK1 is required for subsequent phosphorylation of CSF3R (Shimoda et al. 1997, inferred from mouse homologs). The SRC-related protein kinase LYN is constitutively associated with CSF3R (Corey et al. 1994).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9674546
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9674546