Reaction: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1
- in pathway: Signaling by CSF3 (G-CSF)
After JAK1 is phosphorylated and thereby activated in response to CSF3 binding CSF3R, the resulting p-Y-JAK1 phosphorylates tyrosine residues of the cytosolic domain of CSF3R (Nicholson et al. 1994, Shimoda et al. 1997, inferred from mouse homologs). The phosphorylated tyrosine residues of CSF3R then recruit effector proteins such as kinases, STATs, and RAS activators.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9674558
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9674558