Reaction: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
- in pathway: Signaling by CSF3 (G-CSF)
The kinases JAK2 (Shimoda et al. 1997, Marino and Roguin 2008), TYK2 (Shimoda et al. 1997, Marino and Roguin 2008), HCK, and SYK (Kasper et al. 1999) bind phosphorylated tyrosine residues of the cytosolic domain of CSF3R and are activated by phosphorylation (also inferred from mouse homologs). The order of their binding and the kinases responsible for their phosphorylation are incompletely characterized.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9676071
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9676071