Reaction: Phosphorylation of extracellular domain KIT mutants
- in pathway: Signaling by extracellular domain mutants of KIT
Mutations occurring in the fifth Ig-like extracellular domain of KIT (encoded by exon 8 and 9) are insertions, deletions and duplications affecting codons 502-504 (reviewed in Lennartsson and Roonstrand, 2012; Corless et al, 2011). These variants support ligand-independent autophosphorylation and activation of the receptor dimers (Bodemer et al, 2010; Cammenga et al, 2005).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9680248
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9680248