Reaction: CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine
- in pathway: Signaling by CSF1 (M-CSF) in myeloid cells
In response to CSF1, PLCG2 (phospholipase C gamma2) associates with CSF1R, is activated by phosphorylation, and hydrolyzes phosphatidylcholine to yield choline phosphate (ChoP, phosphocholine) and 1,2-diacylglycerol (Imamura et al. 1990, Nakamura et al. 1992, Obba et al. 2015, also inferred from mouse homologs). PLCG2 activates pathways that enhance differentiation of macrophages (inferred from mouse homologs).
Reaction - small molecule participants:
ChoP [cytosol]
DAGs [plasma membrane]
PC [plasma membrane]
H2O [cytosol]
Reactome.org reaction link: R-HSA-9680388
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Reaction input - small molecules:
1,2-diacyl-sn-glycero-3-phosphocholine
water
Reaction output - small molecules:
phosphocholine
diglyceride
Reactome.org link: R-HSA-9680388