Reaction: Spike protein gets palmitoylated
- in pathway: Maturation of spike protein
Two of the four cysteine-rich clusters of the SARS-CoV-1 spike protein are modified by palmitoylation. This is required for the protein's partitioning into detergent-resistant membranes and for cell–cell fusion. In general, palmitoylation is usually non-enzymatic (Petit et al, 2007; McBride and Machamer, 2010; Veit, 2012).
Reaction - small molecule participants:
CoA-SH [endoplasmic reticulum lumen]
palmitoyl-CoA [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-9683653
======
Reaction input - small molecules:
palmitoyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-9683653