Reaction: N-glycan trimming of Spike
- in pathway: Maturation of spike protein
N-glycan side chains on the nascent SARS-CoV-1 spike protein get their terminal glucose moieties cleaved by ER glucosidases I and II, before folding. Iminosugars inhibit this process and are good candidates for broad-spectrum anivirals (Zhao et al, 2015).
Reaction - small molecule participants:
beta-D-glucose [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-9683663
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Reaction input - small molecules:
water
Reaction output - small molecules:
beta-D-glucose
Reactome.org link: R-HSA-9683663