Reaction: GSK3 phosphorylates Nucleoprotein
- in pathway: Maturation of nucleoprotein
The majority of nucleocapsid protein (N) is serine-phosphorylated in the cytosol and, possibly, in the nucleus where it gets immediately transported to the cytosol. Phosphorylation is catalyzed by glycogen synthase kinase 3 (GSK3A and GSK3B) and several other host cell kinases (Surjit et al, 2005; Wu et al. 2009). GSK3-mediated phosphorylation of the N protein is needed for efficient replication of viral genomic RNA (Wu et al. 2009).
Reaction - small molecule participants:
H+ [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9683664
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
hydron
ADP(3-)
Reactome.org link: R-HSA-9683664