Reaction: Spike protein gets N-glycosylated
- in pathway: Maturation of spike protein
Glycosyltransferases in the endoplasmatic reticulum are responsible for the attachment of numerous high-mannose N-glycans on the SARS-CoV-1 spike protein. After virion assembly and release these glycosidations are required for fusion with host cells (Krokhin et al, 2003; Nal et al, 2005; Ritchie et al, 2010).
Reaction - small molecule participants:
H+ [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-9683755
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Reaction input - small molecules:
Reaction output - small molecules:
hydron
Reactome.org link: R-HSA-9683755