Reaction: pp1a cleaves itself
- in pathway: Maturation of replicase proteins
The crucial step of autocleavage of pp1a involves the formation of an "intermediate" pp1a dimer which has weak protease activity. This "embedded" 3CLp liberates itself by cleaving the ends off its monomer in trans. Only after that the cleaved 3CLp forms a dimer, the most efficient form of the enzyme (Hsu et al, 2005; Chen et al, 2010; Muramatsu et al, 2016).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9684351
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9684351